Asah1是什么
WebObjective: Metabolic deregulation is a key hallmark of cancer cells and has been shown to drive cancer growth and metastasis. However, not all metabolic drivers of melanoma are known. Based on our finding that N-acylsphingosine amidohydrolase 1 (ASAH1) is overexpressed in melanoma, the objective of these studies was to establish its role in … Web24 apr 2024 · Acid ceramidase (aCDase, ASAH1) hydrolyzes lysosomal membrane ceramide into sphingosine, the backbone of all sphingolipids, to regulate many cellular processes. Abnormal function of aCDase leads ...
Asah1是什么
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WebThis publication includes mutations in ASAH1 collected through the Observational and Cross-Sectional Cohort Study of the Natural History and Phenotypic Spectrum of Farber … WebLysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (PubMed:10610716, PubMed:7744740, PubMed:15655246, …
WebASAH1-201 ENSP00000326970 ENST00000314146: Q13510 [Direct mapping] Acid ceramidase Acid ceramidase subunit alpha Acid ceramidase subunit beta. Show all. … Web29 gen 2015 · Zhou et al. (2012) postulated that the different phenotype in these patients was related to residual levels of ASAH1 activity. In a girl with onset of SMAPME manifest as seizures at age 10 years, Dyment et al. (2014) identified compound heterozygous mutations in the ASAH1 gene (613468.0010 and 613468.0011).
Web6 set 2024 · ASAH1 is the enzyme that converts ceramides into sphingosine. Therefore, we detected ceramides by immunostaining using the anti-ceramidase antibody. Web那么 Bash 到底是什么呢？. 长话短说：Bash 也是一种跑在你电脑里的 程序 (program)，但它的设计使你能轻松地与之“对话” (talk)。. 在你电脑里的每个程序都能做很多不同的事：读 …
WebAcid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression In H295R human adrenocortical cells, ACTH rapidly activates ceramide …
WebAn autosomal recessive neuromuscular disorder characterized by childhood onset of motor deficits and progressive myoclonic seizures, after normal developmental … church divinity school of the pacific facultyWebThe ASAH1 gene provides instructions for making an enzyme called acid ceramidase. This enzyme is found in lysosomes, which are cell compartments that digest and recycle … church division crossword clueWeb21 mar 2024 · ASAH1 (N-Acylsphingosine Amidohydrolase 1) is a Protein Coding gene. Diseases associated with ASAH1 include Farber Lipogranulomatosis and Spinal … church divinity school v. alamedaWebThis intriguing property of ASAH1 can be used by cancer cells to their advantage, by increasing the expression of the tumor promoter, sphingosine inside cells, thus creating a favorable environment for cancer growth. The different possibilities through which this enzyme serves its role in formation, progression and resistance of different types ... church divinity school of the pacific caWeb29 mar 2024 · ASAH1 as a pivotal regulator of steroidogenic capacity in the human adrenal cortex. down-regulation of aCDase alone or in combination with DTIC may represent a … church divisionWebASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy ASAH1 pathogenic variants associated with acid ceramidase deficiency: Farber disease and spinal muscular atrophy with progressive myoclonic epilepsy deutsche bank global materials conferenceWeb鞘脂代谢关键酶-ASAH1-酸性神经酰胺酶(N—acylsphingosineamidohydrolase1,ASAH1)是鞘脂代谢的关键酶,其水解神经酰胺,生成鞘氨醇,继而代谢为鞘氨醇-1-磷酸(sphin-gosine-1 … deutsche bank germany annual report