Cthrc1 gene

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August undefined, 2024

WebFeb 8, 2024 · We assessed the cause of elevated CTHRC1 levels. DNA methylation, gene mutation, CNV was critically involved in genetic and epigenetic regulation and were … WebOct 6, 2024 · According to the previous reports, the collagen triple helix repeat containing 1 (CTHRC1) causes tumorigenesis by modulating the tumor microenvironment, however, the evidence is limited to a few human cancer subtypes. ... (GEO) based datasets. During the analysis, we simply queue the CTHRC1 gene in these databases to acquire the KM …

Identification and Verification of Potential Biomarkers in Gastric ...

WebCTHRC1. PROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA. CTHRC1 INFORMATION. Proteini. Full gene name according to HGNC. Collagen triple … WebCTHRC1 is a Potential Prognostic Biomarker and Correlated with Macrophage Infiltration in Breast Cancer . Fulltext; Metrics; Get Permission; Cite this article; Authors Wang Z, Zhang S, Zheng C, Xia K, Sun L, Tang X, Zhou F, Ouyang Y, Tang F. Received 13 March 2024. can a trait that is not heritable evolve

Treatment of cholestatic fibrosis by altering gene expression of Cthrc1 …

WebELISA Kits by Target . ELISA (enzyme-linked immunosorbent assay) is a plate-based technique for detection and quantification of antibodies or proteins such as cytokines, chemokines, growth factors, hormones, and intracellular phosphorylated proteins. WebJul 19, 2024 · Collagen triple helix repeat containing-1 (CTHRC1), highly expressed in multiple human solid tumors, has been identified as a tumor associated protein. … WebOct 8, 2012 · Generation of Cthrc1 null mice. (A) Cthrc1 gene targeting schematic showing replacement of exons 2-4 with a PGK-neo cassette. (B) Embryonic stem cell targeting with Southern blot analysis of ... fish house rental

CTHRC1 expression is a novel shared diagnostic and prognostic biomarker ...

Cthrc1, a Novel Circulating Hormone Regulating Metabolism

WebWe recently identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene induced in adventitial fibroblasts after arterial injury. Cthrc1 is a 30 kDa secreted protein that has the ability to inhibit collagen matrix synthesis. Cthrc1 is also glycosylated and retains a signal sequence consistent with the presence of Cthrc1 in the ... WebMay 13, 2024 · A Relative mRNA level of CTHRC1 in primary CRC with metastasis (Mets) and primary CRC without (w/o) Mets using three … fish house rental buffalo mnWebMethods: DEGs were screened from four GEO (Gene Expression Omnibus) gene expression profiles. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed. ... Collagen Type X Alpha 1 Chain (COL10A1), Collagen Triple Helix Repeat Containing 1 (CTHRC1), and Fibroblast Activation Protein (FAP) … fish house removal mn map

"WebMar 20, 2024 · Correlations between CTHRC1 gene expression and clinicopathological factors were analyzed using gene expression data from UALCAN databases. Then, we searched the GEPIA database to evaluate the association of CTHRC1 gene expression with clinical outcomes. The cBioPortal database was used to analyze CTHRC1 genetic … " - Cthrc1 gene

Cthrc1 gene

Overexpression of CTHRC1 in Hepatocellular Carcinoma Promotes …

WebMar 21, 2024 · CTHRC1 (Collagen Triple Helix Repeat Containing 1) is a Protein Coding gene. Diseases associated with CTHRC1 include Barrett Esophagus and Adenocarcinoma . Among its related pathways are Wnt … WebSep 9, 2008 · Methodology/Principal Findings. We identified collagen triple helix repeat containing-1 (Cthrc1) as a downstream target of bone morphogenetic protein-2 (BMP2) in osteochondroprogenitor-like cells by PCR-based suppression subtractive hybridization followed by differential hybridization, and found that Cthrc1 was expressed in bone …

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WebOct 8, 2012 · Background We discovered the gene Collagen Triple Helix Repeat Containing 1 (Cthrc1) and reported its developmental expression and induction in adventitial cells of injured arteries and dermal cells of skin wounds. The role of Cthrc1 in normal adult tissues has not yet been determined. Methodology/Principal Findings We … WebGenomic Mutations. 2 involving Cthrc1. Incidental Mutations. Mutagenetix , APF. Find Mice (IMSR) 20 strains or lines available. Comparison Matrix. Gene Expression + Phenotype. …

WebOct 26, 2024 · The function of collagen triple helix repeat containing 1 (CTHRC1) as an oncogene has been reported in a growing number of publications. Bioinformatics methods represent a beneficial approach to examine the mechanism and function of the CTHRC1 gene in the disease process of cancers from a pan-cancer perspective. In this study, … WebTreatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease Author links open overlay panel Zhaolian Bian a 1 , Qi Miao a 1 , Wei Zhong a 1 , Haiyan Zhang a , Qixia Wang a , Yanshen Peng a , Xiaoyu Chen a , Canjie Guo a , Li Shen a , Fan Yang a , Jie Xu a , Dekai Qiu a ...

http://www.informatics.jax.org/marker/MGI:1915838 WebCTHRC1 is known to regulate extracellular collagen deposition and partake in vascular remodeling of arterial injury as a function of cellular response through the TGF-β and Wnt pathways. Moreover, mutation of the gene has been associated with carcinogenesis in a variety of cell and tissues, most notably esophageal adenocarcinoma and Barrett ...

WebMar 21, 2024 · CTHRC1 serves as a pro-metastatic gene that contributes to NSCLC invasion and metastasis, which are mediated by upregulated MMP7 and MMP9 …

WebDec 22, 2024 · The X-axis represent ligand and receptor pairs, with the first gene expressed on F13-Act-CTHRC1 cells and second gene expressed on the interacting cell types denoted in the Y-axis. Red: upregulated gene in tumor bulk RNA-seq. Blue: downregulated in tumor bulk (none present). fish house rental gull lakeWebFeb 22, 2007 · We identified collagen triple helix repeat containing-1 (Cthrc1) as a novel gene expressed in the adventitia and neointima on arterial injury and found that it functionally increases cell migration while reducing collagen deposition. To address the in vivo role of Cthrc1, we generated transgenic mouse lines that constitutively overexpress … fish house rentals in minnesotaWebSep 23, 2024 · Through bioinformatics analyses and experiments, we confirmed that CTHRC1 is highly expressed in tissues and hepatoma cell lines. High expression of the CTHRC1 gene is associated with poor prognosis. Collectively, the results of the present study indicated that CTHRC1 may serve as a prognostic biomarker for HCC. can a-train run on waterWebby Gene › by Protein › CTHRC1 Antibodies; CTHRC1 Antibodies . Antibodies that detect CTHRC1 can be used in several scientific applications, including Western Blot, Immunohistochemistry, ELISA, Immunocytochemistry and Immunoprecipitation. These antibodies target CTHRC1 in Human, Mouse and Rat samples. Our CTHRC1 polyclonal, … can a traffic violation in be negotiatedWebCollagen triple helix repeat containing 1 is a protein that in humans is encoded by the CTHRC1 gene. Function. This locus encodes a protein that may play a role in the … fish house rentals devils lake ndWebFeb 8, 2024 · Introduction. The collagen triple helix repeat containing 1 (Cthrc1) gene was first reported by the Lindner laboratory in a screen for genes differentially expressed upon major damage to arteries in rats (Pyagay et al. 2005).Cthrc1 was highly induced in injured arteries, with expression subsiding upon healing (Pyagay et al. 2005; LeClair et … can a tramatic event cause a heart attackWebGene view. The gene view histogram is a graphical view of mutations across CTHRC1. These mutations are displayed at the amino acid level across the full length of the gene … can a transfer on death be contested