WebbNCOA2 rearrangements were found in two additional spindle cell RMS from a 3-month-old and a 4-week-old child. In the latter tumor, TEAD1 was identified by rapid amplification of … WebbWe describe a novel fusion gene, GREB1-NCOA2, detected by transcriptome sequencing and validated by reverse transcriptase polymerase chain reaction and Sanger sequencing in an undifferentiated uterine sarcoma. The chimeric transcript was an in-frame fusion between exon 3 of GREB1 and exon 15 of NCOA2.

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WebbIn this study, we established a cell line (S-RMS1) derived from a four-month-old boy with infantile spindle cell RMS harboring SRF-NCOA2 gene fusion. Methods: Morphological and molecular characteristics of S-RMS1 were analyzed and compared with two RMS cell lines, RH30 and RD18. WebbSarcomas with MEIS1-NCOA2 fusions have been so far reported in 2 cases each of primitive renal sarcomas and intraosseous pelvic rhabdomyosarcomas. Their histologic spectrum, anatomic distribution, and clinical behavior remain poorly defined. In this study, we report 6 additional spindle cell sarcomas with MEIS1-NCOA2 or NCOA1 fusions that … loomis fredericton

VGLL2-NCOA2 leverages developmental programs for pediatric ...

Webb19 juli 2024 · Spindle cell and sclerosing rhabdomyosarcoma (ssRMS) is a rare variant of rhabdomyosarcoma, which includes three distinct subtypes. In infants, these tumors are … Webb270 La radiologia medica (2024) 124:266–281 1 3 Table 2 Genefusionsinsoft tissueneoplasm Tumor Genefusion Cytogenetics Lipoma EBF1-LOC204010 HMGA2-CXCR7 Webb1 juni 2024 · TEAD1-NCOA2 n = 4, partner unknown n = 1. b VGLL2-CITED2 n = 2, partner unknown n = 4. c One sample only tested for NCOA2 and 2 samples only tested for VGLL2 containing fusions. 3.2. Patients with localized disease Thirty-nine patients had localized disease: IRS I (n = 12), IRS II (n = 6) and IRS III (n = 20); n.a. (n = 1). loomis franklin school