Web19. mar 2024 · Using Top2α inhibitor (ICRF193 or Etoposide)-treated primary T cells as a model, we demonstrated that disrupting the DNA topology promoted DNA damage and T … Web15. sep 2024 · The invention relates to novel compositions, combinations and methods relating to compounds which inhibit EZH2 and their uses for treating and/or preventing tumors associated with methyltransferase EZH2. More specifically the invention relates to synergistic bi-therapy compositions for use in a method of treating and/or preventing …
Study on the expression of TOP2A in hepatocellular carcinoma …
Web2. nov 2024 · First, we compared the effects of inhibitors of three RNA polymerases (Pol) on EGFP-TOP2A (Fig. 5a) and EGFP-TOP2B (Fig. 5b). Cells were pretreated with one of the Pol inhibitors and subsequently ... WebEleven of 14 TOP2A inhibitors had an antiproliferative effect in the NCI-H295R ACC cell line. The dose–response titration curve of the 11 most active drugs showed that aclarubicin had the most potent activity among TOP2A inhibitors evaluated (Fig. 4). Aclarubicin is an antitumor anthracycline drug that has been used in patients with acute ... millennium 3 cry wolf walkthrough
Molecules Free Full-Text The Inhibition of miR-144-3p on Cell ...
Web24. máj 2024 · Here we show that the long non-coding satellite III RNA (SatIII) generates resistance against the topoisomerase IIa (TOP2A) inhibitor etoposide in lung cancer. Because heat shock conditions (HS ... Web10. dec 2024 · Taken together, these results show that miR-144-3p inhibited growth and promoted apoptosis in glioma cells by targeting TOP2A. Glioblastoma (GBM), the most … Currently, topoisomerase inhibitors hold a prominent place among antibiotics and anticancer drugs in active medical use, as inhibitors like doxorubicin (anthracycline, TopII inhibitor), etoposide (TopII inhibitor), ciprofloxaxin (fluoroquinolone, TopII inhibitor), and irinotecan (camptothecin derivative, TopI … Zobraziť viac Topoisomerase inhibitors are chemical compounds that block the action of topoisomerases, which are broken into two broad subtypes: type I topoisomerases (TopI) and type II topoisomerases (TopII). Topoisomerase … Zobraziť viac Mechanism TopII forms a homodimer that functions by cleaving double stranded DNA, winding a second DNA duplex through the gap, and re-ligating the strands. TopII is necessary for cell proliferation and is abundant in cancer cells, … Zobraziť viac • Antony S, Agama KK, Miao ZH, Takagi K, Wright MH, Robles AI, Varticovski L, Nagarajan M, Morrell A, Cushman M, Pommier Y (Nov 2007). • Antony S, Agama KK, Miao ZH, … Zobraziť viac In the 1940s, great strides were made in the field of antibiotic discovery by researchers like Albert Schatz, Selman A. Waksman, and H. Boyd Woodruff that inspired … Zobraziť viac Mechanism TopI relaxes DNA supercoiling during replication and transcription. Under normal circumstances, … Zobraziť viac Synthetic lethality arises when a combination of deficiencies in the expression of two or more genes leads to cell death, … Zobraziť viac millennium 3 financial services pty ltd